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Journal Article

Structural basis of mitochondrial transcription.


Hillen,  H. S.
Research Group Structure and Function of Molecular Machines, MPI for Biophysical Chemistry, Max Planck Society;


Cramer,  P.
Department of Molecular Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Hillen, H. S., Temiakov, D., & Cramer, P. (2018). Structural basis of mitochondrial transcription. Nature Structural and Molecular Biology, 25(9), 754-765. doi:10.1038/s41594-018-0122-9.

Cite as: http://hdl.handle.net/21.11116/0000-0002-0FFE-1
The mitochondrial genome is transcribed by a single-subunit DNA-dependent RNA polymerase (mtRNAP) and its auxiliary factors. Structural studies have elucidated how mtRNAP cooperates with its dedicated transcription factors to direct RNA synthesis: initiation factors TFAM and TFB2M assist in promoter-DNA binding and opening by mtRNAP while the elongation factor TEFM increases polymerase processivity to the levels required for synthesis of long polycistronic mtRNA transcripts. Here, we review the emerging body of structural and functional studies of human mitochondrial transcription, provide a molecular movie that can be used for teaching purposes and discuss the open questions to guide future directions of investigation.