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Journal Article

Liposomes and polymersomes : a comparative review towards cell mimicking


Dimova,  Rumiana
Rumiana Dimova, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Rideau, E., Dimova, R., Schwille, P., Wurm, F. R., & Landfester, K. (2018). Liposomes and polymersomes: a comparative review towards cell mimicking. Chemical Society Reviews, 47(23), 8572-8610. doi:10.1039/C8CS00162F.

Cite as: http://hdl.handle.net/21.11116/0000-0002-1554-8
Cells are integral to all forms of life due to their compartmentalization by the plasma membrane. However, living organisms are immensely complex. Thus there is a need for simplified and controllable models of life for a deeper understanding of fundamental biological processes and man-made applications. This is where the bottom-up approach of synthetic biology comes from: a stepwise assembly of biomimetic functionalities ultimately into a protocell. A fundamental feature of such an endeavor is the generation and control of model membranes such as liposomes and polymersomes. We compare and contrast liposomes and polymersomes for a better a priori choice and design of vesicles and try to understand the advantages and shortcomings associated with using one or the other in many different aspects (properties, synthesis, self-assembly, applications) and which aspects have been studied and developed with each type and update the current development in the field.