Deutsch
 
Benutzerhandbuch Datenschutzhinweis Impressum Kontakt
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Histone H3 phosphorylation during Xenopus oocyte maturation: Regulation by the MAP kinase/p90Rsk pathway and uncoupling from DNA condensation.

MPG-Autoren
/persons/resource/persons225731

Lenart,  P.
Research Group of Cytoskeletal Dynamics in Oocytes, MPI for Biophysical Chemistry, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Schmitt, A., Gutierrez, G. J., Lenart, P., Ellenberg, J., & Nebreda, A. R. (2002). Histone H3 phosphorylation during Xenopus oocyte maturation: Regulation by the MAP kinase/p90Rsk pathway and uncoupling from DNA condensation. FEBS Letters, 518(1-13), 23-28. doi:10.1016/S0014-5793(02)02630-3.


Zitierlink: http://hdl.handle.net/21.11116/0000-0002-129E-8
Zusammenfassung
Here we show that during the meiotic maturation of Xenopus oocytes, histone H3 becomes phosphorylated on serine-10 at about the time of maturation promoting factor activation and meiosis I entry. However, overexpression of cAMP-dependent protein kinase that blocks entry into M phase, also leads to massive serine-10 phosphorylation of histone H3 in intact Xenopus oocytes but does not cause chromosome condensation. We also show that the phosphorylation of histone H3 during oocyte maturation requires the activation of the mitogen-activated protein kinase/p90Rsk pathway. Our results indicate that in G2-arrested oocytes, which are about to enter M phase, histone H3 phosphorylation is not sufficient for chromosome condensation.