Human organomics: a fresh approach to understanding human development using 
single-cell transcriptomics.

Camp, J Gray; Treutlein, Barbara

doi:10.1242/dev.150458

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Human organomics: a fresh approach to understanding human development using single-cell transcriptomics.

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Camp, J. G., & Treutlein, B. (2017). Human organomics: a fresh approach to understanding human development using single-cell transcriptomics. Development (Cambridge, England), 144(9), 1584-1587. doi:10.1242/dev.150458.

Cite as: https://hdl.handle.net/21.11116/0000-0002-8C35-5

Abstract

Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these 'organoids' into constituent parts, and reconstruct lineage trajectories during cell differentiation. In this Spotlight article we summarize the different approaches to performing single-cell transcriptomics on organoids, and discuss the opportunities and challenges of applying these techniques to generate organ-level, mechanistic models of human development and disease. Together, these technologies will move past characterization to the prediction of human developmental and disease-related phenomena.