RNA gets in phase.

Saha, Shambaditya; Hyman, Anthony

doi:10.1083/jcb.201706034

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RNA gets in phase.

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Saha, S., & Hyman, A. (2017). RNA gets in phase. The Journal of cell biology, 216(8), 2235-2237. doi:10.1083/jcb.201706034.

Cite as: https://hdl.handle.net/21.11116/0000-0002-8CB2-7

Abstract

Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene. Jain and Vale (2017. Nature. https://doi.org/10.1038/nature22386) show that, above a pathological threshold repeat number, base pairing interactions drive phase separation of RNA into membrane-less gels, suggesting that RNA can scaffold the assembly of phase-separated compartments that sequester proteins/RNAs causing toxicity.