Stardust, the Janus-faced partner of Crumbs.

Das, Shradha; Knust, Elisabeth

doi:10.1083/jcb.201704023

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Stardust, the Janus-faced partner of Crumbs.

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Das, S., & Knust, E. (2017). Stardust, the Janus-faced partner of Crumbs. The Journal of cell biology, 216(5), 1219-1221. doi:10.1083/jcb.201704023.

Cite as: https://hdl.handle.net/21.11116/0000-0002-8C55-1

Abstract

The Drosophila melanogaster scaffolding protein Stardust (Sdt) stabilizes the transmembrane protein Crumbs, a conserved regulator of apical-basal epithelial polarity. In this issue, Perez-Mockus et al. (2017. J. Cell Biol https://doi.org/10.1083/jcb.201611196) report that a subset of Sdt isoforms are targeted by the ubiquitin ligase Neuralized, thus fine tuning the endocytosis and activity of this apical determinant.