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Simulation of 13C Labeling Effects in 1H MRS with different Sequences at 9.4 T

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Ziegs,  T
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84402

Henning,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Ziegs, T., & Henning, A. (2018). Simulation of 13C Labeling Effects in 1H MRS with different Sequences at 9.4 T. Poster presented at MRS Workshop 2018 Metabolic Imaging, Utrecht, The Netherlands.


Cite as: http://hdl.handle.net/21.11116/0000-0002-4434-7
Abstract
Glutamate related metabolism can be measured considering the 13C labeling effects from an administered 13C labeled substrate in 1H MR spectra without 13C channels. The advantage of this technique is that some challenges of 13C MRS like non-standard hardware modifications etc. are avoided and the simultaneous observation of 12C- and 13 C-coupled protons is possible. On the other hand the latter also complicates the spectra. In this work, different sequences will be compared to optimize spectral resolution for glutamate and glutamine at 9.4 T.