A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping 
for in vivo evaluation of articular cartilage

Juras, V; Bohndorf, K; Heule, R; Kronnerwetter, C; Szomolanyi, P; Hager, B; Bieri, O; Zbyn, S; Trattnig, S

doi:10.1007/s00330-015-3979-6

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A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage

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Citation

Juras, V., Bohndorf, K., Heule, R., Kronnerwetter, C., Szomolanyi, P., Hager, B., et al. (2016). A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage. European Radiology, 26(6), 1905-1912. doi:10.1007/s00330-015-3979-6.

Cite as: https://hdl.handle.net/21.11116/0000-0002-45A2-9

Abstract

Objectives
To assess the clinical relevance of T2 relaxation times, measured by 3D triple-echo steady-state (3D-TESS), in knee articular cartilage compared to conventional multi-echo spin-echo T2-mapping.
Methods
Thirteen volunteers and ten patients with focal cartilage lesions were included in this prospective study. All subjects underwent 3-Tesla MRI consisting of a multi-echo multi-slice spin-echo sequence (CPMG) as a reference method for T2 mapping, and 3D TESS with the same geometry settings, but variable acquisition times: standard (TESSs 4:35min) and quick (TESSq 2:05min). T2 values were compared in six different regions in the femoral and tibial cartilage using a Wilcoxon signed ranks test and the Pearson correlation coefficient (r). The local ethics committee approved this study, and all participants gave written informed consent.
Results
The mean quantitative T2 values measured by CPMG (mean: 46±9ms) in volunteers were significantly higher compared to those measured with TESS (mean: 31±5ms) in all regions. Both methods performed similarly in patients, but CPMG provided a slightly higher difference between lesions and native cartilage (CPMG: 90ms→61ms [31%],p=0.0125;TESS 32ms→24ms [24%],p=0.0839).
Conclusions
3D-TESS provides results similar to those of a conventional multi-echo spin-echo sequence with many benefits, such as shortening of total acquisition time and insensitivity to B1 and B0 changes.