Mannose-functionalized nanoscaffolds for targeted delivery in biomedical 
applications

Hu, Jing; Wei, Peng; Seeberger, Peter H.; Yin, Jian

doi:10.1002/asia.201801088

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Mannose-functionalized nanoscaffolds for targeted delivery in biomedical applications

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Seeberger, Peter H.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Hu, J., Wei, P., Seeberger, P. H., & Yin, J. (2018). Mannose-functionalized nanoscaffolds for targeted delivery in biomedical applications. Chemistry – An Asian Journal, 13(22), 3448-3459. doi:10.1002/asia.201801088.

Cite as: https://hdl.handle.net/21.11116/0000-0002-5433-6

Abstract

Targeted delivery nanomaterials have been extensively investigated as an effective strategy to surmount obstacles in conventional treatment of cancer and infectious
diseases, such as systemic toxicity, low drug efficacy, and drug resistance. Mannose-binding C-type lectins, mainly including MR and DC-SIGN, are highly expressed on various cancer cells, endothelial cells, macrophages and dendritic cells (DCs), which make them attractive targets for therapeutic effect. Mannosylated nanomaterials hold great potential in cancer and infection treatment by direct therapeutic effect on targeted cells, modulation of tumor microenvironment and stimulation of immune
response via antigen presentation. This review presents the recent advances of mannose-based targeted delivery nanoplatforms incorporated with different therapies in the biomedical field.