P2X7 Receptor: A Potential Therapeutic Target for Depression?

Deussing, Jan M.; Arzt, Eduardo

doi:10.1016/j.molmed.2018.07.005

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P2X7 Receptor: A Potential Therapeutic Target for Depression?

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Deussing, Jan M.
RG Molecular Neurogenetics, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Deussing, J. M., & Arzt, E. (2018). P2X7 Receptor: A Potential Therapeutic Target for Depression? TRENDS IN MOLECULAR MEDICINE, 24(9), 736-747. doi:10.1016/j.molmed.2018.07.005.

Cite as: https://hdl.handle.net/21.11116/0000-0003-5EDF-A

Abstract

Depression is a prime contributor to global disease burden with 300 million affected patients worldwide. The persistent lack of progress with regards to pharmacotherapy stands in stark contrast to the pandemic magnitude of the disease. Alterations of inflammatory pathways in depressed patients, including altered circulating pro-inflammatory cytokines, have been put forward as a potential pathophysiological mechanism. The P2X7 receptor (P2X7R) plays an important role regulating the release of interleukin-1 beta and other cytokines. Comprehensive investigation of the P2X7R Gln460Arg missense mutation (rs2230912), which has been associated with major depression and bipolar disorder, has substantially contributed to validate P2X7R as a potential genetic risk factor. We propose that P2X7R is a putative target with good prospects for therapeutic intervention in depressive disorders.