DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in 
multiple sclerosis

Kular, Lara; Liu, Yun; Ruhrmann, Sabrina; Zheleznyakova, Galina; Marabita, Francesco; Gomez-Cabrero, David; James, Tojo; Ewing, Ewoud; Linden, Magdalena; Gornikiewicz, Bartosz; Aeinehband, Shahin; Stridh, Pernilla; Link, Jenny; Andlauer, Till F. M.; Gasperi, Christiane; Wiendl, Heinz; Zipp, Frauke; Gold, Ralf; Tackenberg, Bjoern; Weber, Frank; Hemmer, Bernhard; Strauch, Konstantin; Heilmann-Heimbach, Stefanie; Rawal, Rajesh; Schminke, Ulf; Schmidt, Carsten O.; Kacprowski, Tim; Franke, Andre; Laudes, Matthias; Dilthey, Alexander T.; Celius, Elisabeth G.; Sondergaard, Helle B.; Tegner, Jesper; Harbo, Hanne F.; Oturai, Annette B.; Olafsson, Sigurgeir; Eggertsson, Hannes P.; Halldorsson, Bjarni V.; Hjaltason, Haukur; Olafsson, Elias; Jonsdottir, Ingileif; Stefansson, Kari; Olsson, Tomas; Piehl, Fredrik; Ekstroem, Tomas J.; Kockum, Ingrid; Feinberg, Andrew P.; Jagodic, Maja

doi:10.1038/s41467-018-04732-5

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

MPS-Authors

/persons/resource/persons125664

Andlauer, Till F. M.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;
external;

/persons/resource/persons80578

Weber, Frank
Max Planck Institute of Psychiatry, Max Planck Society;
external;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

41467_2018_Article_4732.pdf
(出版社版), 2MB

付随資料 (公開)

There is no public supplementary material available

引用

Kular, L., Liu, Y., Ruhrmann, S., Zheleznyakova, G., Marabita, F., Gomez-Cabrero, D., James, T., Ewing, E., Linden, M., Gornikiewicz, B., Aeinehband, S., Stridh, P., Link, J., Andlauer, T. F. M., Gasperi, C., Wiendl, H., Zipp, F., Gold, R., Tackenberg, B., Weber, F., Hemmer, B., Strauch, K., Heilmann-Heimbach, S., Rawal, R., Schminke, U., Schmidt, C. O., Kacprowski, T., Franke, A., Laudes, M., Dilthey, A. T., Celius, E. G., Sondergaard, H. B., Tegner, J., Harbo, H. F., Oturai, A. B., Olafsson, S., Eggertsson, H. P., Halldorsson, B. V., Hjaltason, H., Olafsson, E., Jonsdottir, I., Stefansson, K., Olsson, T., Piehl, F., Ekstroem, T. J., Kockum, I., Feinberg, A. P., & Jagodic, M. (2018). DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis. NATURE COMMUNICATIONS, 9:. doi:10.1038/s41467-018-04732-5.

引用: https://hdl.handle.net/21.11116/0000-0003-5CBD-2

要旨

The human leukocyte antigen (HLA) haplotype DRB1(star)15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1(star)15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1(star)15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 is particularly affected and displays methylation-sensitive regulatory properties in vitro. Causal inference and Mendelian randomization provide evidence that HLA variants mediate risk for MS via changes in the HLA-DRB1 DMR that modify HLA-DRB1 expression. Meta-analysis of 14,259 cases and 171,347 controls confirms that these variants confer risk from DRB1(star)15:01 and also identifies a protective variant (rs9267649, p < 3.32 x 10(-8), odds ratio = 0.86) after conditioning for all MS-associated variants in the region. rs9267649 is associated with increased DNA methylation at the HLA-DRB1 DMR and reduced expression of HLA-DRB1, suggesting a modulation of the DRB1(star)15:01 effect. Our integrative approach provides insights into the molecular mechanisms of MS susceptibility and suggests putative therapeutic strategies targeting a methylation-mediated regulation of the major risk gene.