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Journal Article

Hypothalamic miR-219 regulates individual metabolic differences in response to diet-induced weight cycling

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Schroeder,  Mariana
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
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Drori,  Yonat
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
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Ben-Efraim,  Yair J
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
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Chen,  Alon
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
external;

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Citation

Schroeder, M., Drori, Y., Ben-Efraim, Y. J., & Chen, A. (2018). Hypothalamic miR-219 regulates individual metabolic differences in response to diet-induced weight cycling. MOLECULAR METABOLISM, 9, 176-186. doi:10.1016/j.molmet.2018.01.015.


Cite as: https://hdl.handle.net/21.11116/0000-0002-5E64-5
Abstract
Consumption of a low calorie diet is the most common approach to lose weight. While generally effective at first, it is frequently followed by a relapse where the pre-diet weight is regained, and often exceeded. This pattern of repeated weight loss/regain is referred to as weight cycling and the resulting metabolic response varies greatly between individuals.
Objective: We attempted to address the issue of individual differences in the response to weight cycling in male mice.
Methods: We first exposed adult wild type mice to repeated cycles of high/low fat food. Next, using a lentiviral approach, we knocked-down or over-expressed miR-219 in the ventromedial hypothalamus (VMH) of an additional mouse cohort and performed a full metabolic assessment.
Results: Exposure of wild type males to weight cycling resulted in the division of the cohort into subsets of resistant versus metabolic syndrome-prone (MS) animals, which differed in their metabolic profile and hypothalamic miR-219 levels. Lentiviral knock-down of miR-219 in the VMH led to exacerbation of metabolic syndrome. In contrast, over-expression of miR-219 resulted in moderation of the metabolic syndrome phenotype.
Conclusions: Our results suggest a role for miR-219 in the mediation of the metabolic phenotype resulting from repeated weight cycling. (C) 2018 The Authors. Published by Elsevier GmbH.