An integrated lab-on-a-chip approach to study heterogeneous enantioselective 
catalysts at the microscale

Warias, Rico; Zaghi, Anna; Heiland, Josef J.; Piendl, Sebastian K.; Gilmore, Kerry; Seeberger, Peter H.; Massi, Alessandro; Belder, Detlev

doi:10.1002/cctc.201801637

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An integrated lab-on-a-chip approach to study heterogeneous enantioselective catalysts at the microscale

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Gilmore, Kerry
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger, Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Warias, R., Zaghi, A., Heiland, J. J., Piendl, S. K., Gilmore, K., Seeberger, P. H., et al. (2018). An integrated lab-on-a-chip approach to study heterogeneous enantioselective catalysts at the microscale. ChemCatChem, 10(23), 5382-5385. doi:10.1002/cctc.201801637.

Cite as: https://hdl.handle.net/21.11116/0000-0002-6864-9

Abstract

An integrated lab-on-a-chip enables the rapid analysis of heterogenized enantioselective organocatalysis at the microscale. A packed-bed microreactor was seamlessly integrated with a downstream chiral high pressure liquid chromatography (HPLC) functionality to study enantioselective transformations on a single microfluidic glass chip. Hyphenation to mass spectrometry allows for the rapid investigation of the selectivity and the substrate scope of microgram amounts of catalyst beads. Optimization of reaction conditions is possible with minimal reagent consumption and instant analytical feedback.