English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes

MPS-Authors
/persons/resource/persons56796

Lenz,  Tobias L.
Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons71686

Hafer-Hahmann,  Nina
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons56896

Samonte,  Irene E.
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons57017

Yeates,  Sarah E.
Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons56825

Milinski,  Manfred
Emeritus Group Milinski, Max Planck Institute for Evolutionary Biology, Max Planck Society;

External Ressource
Fulltext (public)

Lenz_2018_Evolution.pdf
(Publisher version), 578KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Lenz, T. L., Hafer-Hahmann, N., Samonte, I. E., Yeates, S. E., & Milinski, M. (2018). Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes. Evolution, 72(11), 2478-2490. doi:10.1111/evo.13591.


Cite as: http://hdl.handle.net/21.11116/0000-0002-673D-7
Abstract
Abstract Females choose specific mates in order to produce fitter offspring. However, several factors interfere with females' control over fertilization of their eggs, including sneaker males and phenotypically unpredictable allele segregation during meiosis. Mate choice at the individual level thus provides only a poor approximation for obtaining the best genetic match. Consequently, postcopulatory sperm selection by female oocytes has been proposed as a mechanism to achieve complementary combinations of parental haplotypes. Here, using controlled in vitro fertilization of three-spined stickleback eggs, we find haplotype-specific fertilization bias toward gametes with complementary major histocompatibility complex (MHC) immunogenes. The resulting zygote (and thus offspring) genotypes exhibit an intermediate level of individual MHC diversity that was previously shown to confer highest pathogen resistance. Our finding of haplotype-specific gamete selection thus represents an intriguing mechanism for fine-tuned optimization of the offspring's immune gene composition and an evolutionary advantage in the Red Queen dynamics of host-parasite coevolution.