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Journal Article

Evolution of pallium, hippocampus and cortical cell types revealed by single-cell transcriptomics in reptiles

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Citation

Tosches, M. A., Yamawaki, T., Naumann, R., Jacobi, A. A., & Tushev, G. (2018). Evolution of pallium, hippocampus and cortical cell types revealed by single-cell transcriptomics in reptiles. Science, 360, 881-888. doi:10.1126/science.aar4237.


Cite as: https://hdl.handle.net/21.11116/0000-0002-743A-B
Abstract
Computations in the mammalian cortex are carried out by glutamatergic and GABAergic neurons forming specialized circuits and areas. Here we asked how these neurons and areas evolved in amniotes. We built a gene expression altas of the pallium of two reptilian species using large-scale single-cell mRNA sequencing. The transcriptomic signature of glutamatergic neurons in reptilian cortex suggests that mammalian neocortical layers are made of new cell types generated by diversification of ancestral gene regulatory programs. By contrast, the diversity of reptilian cortical GABAergic neurons indicates that the interneuron classes known in mammals already existed in the common ancestor of all amniotes.