Muscle group specific quantification of unsaturated fatty acids by localized 
DEPT-enhanced 13C MRS and ERETIC

Chen, X; Henning, A; Heinzer-Schweizer, S; Pavan, M; Bösiger, P

doi:10.1515/BMT.2010.498

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Muscle group specific quantification of unsaturated fatty acids by localized DEPT-enhanced 13C MRS and ERETIC

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https://www.degruyter.com/downloadpdf/j/bmte.2010.55.issue-s1/bmt.2010.701/bmt.2010.701.pdf
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Chen, X., Henning, A., Heinzer-Schweizer, S., Pavan, M., & Bösiger, P. (2010). Muscle group specific quantification of unsaturated fatty acids by localized DEPT-enhanced 13C MRS and ERETIC. Biomedical Engineering / Biomedizinische Technik, 55(Supplement 1), 182-183.

Cite as: https://hdl.handle.net/21.11116/0000-0002-993A-1

Abstract

The concentration of unsaturated fatty acids in human skeletal muscles can be used to assess the dietary intake with in vivo 13C MR spectroscopy. However the variety of muscle fiber groups may result in the difference of absolute concentration of the metabolites. The inherent low sensitivity and multiple structures restrict the quantification of metabolic concentrations of specific localized 13C spectra. We propose a combined SNR enhancement method by proton decoupling and ISIS-localized DEPT, aiming at muscle-group specific detection of unsaturated fatty acid in the calf muscle. With the chosen enhancement method in vivo calf muscle spectra from small volumes of interest in specific muscle fiber groups can be acquired and quantified using the ERETIC signal as a synthetic reference standard.