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Journal Article

Dual time-point [18F]florbetaben PET delivers dual biomarker information in mild cognitive impairment and Alzheimer's disease

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Schroeter,  Matthias L.
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Florek, L., Tiepolt, S., Schroeter, M. L., Berrouschot, J., Saur, D., Hesse, S., et al. (2018). Dual time-point [18F]florbetaben PET delivers dual biomarker information in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease, 66(3), 1105-1116. doi:10.3233/JAD-180522.


Cite as: https://hdl.handle.net/21.11116/0000-0002-9E01-B
Abstract
BACKGROUND:

Current research diagnostic criteria for Alzheimer's disease (AD) and mild cognitive impairment (MCI) due to AD include biomarkers to supplement clinical testing. Recently, we demonstrated that dual time-point [18F]FBB PET is able to deliver both blood flow and amyloid-β (Aβ) load surrogates.
OBJECTIVE:

The aim of this study was to investigate whether these surrogates can be utilized as AD biomarkers.
METHODS:

112 subjects (41 with MCI, 50 with probable/possible AD, 21 with other dementias) underwent dual time-point [18F]FBB PET. Data were visually and relative quantitatively (Herholz scores for the early and composite SUVRs for the late PET data) analyzed.
RESULTS:

In the early images AD-typical patterns were present in 42% /27% /33% of probable/possible AD/MCI/other dementia cases. In late [18F]FBB PET, 42% /29% /38% of probable/possible AD/ MCI/other dementia cases were Aβ-positive. 17% of the MCIs were categorized as "MCI due to AD-high likelihood", 44% of the probable ADs as "probable AD with high evidence of AD pathophysiological process" and 28% of the possible ADs as "possible AD with evidence of AD pathophysiological process". 27% of all subjects showed a positive diagnostic and progression biomarker. Herholz scores were lower (0.85±0.05 versus 0.88±0.04, p = 0.015) for probable/possible AD versus MCI. Composite late phase SUVRs were significantly higher (1.65±0.23 versus 1.15±0.17, p < 0.005) in Aβ-positive versus Aβ-negative patients. Herholz and MMSE scores were positively correlated (R = 0.30 p = 0.006).
CONCLUSION:

Dual time-point [18F]FBB PET provides dual biomarker information which enables to categorize MCI and AD dementia patients according to established diagnostic criteria. Thus, dual time-point [18F]FBB PET has great potential to supplement diagnostic dementia workups.