Structural characterization of EasH (Aspergillus japonicus) - an oxidase 
involved in cycloclavine biosynthesis

Jakubczyk, Dorota; Caputi, Lorenzo; Stevenson, Clare E. M.; Lawson, David M.; O'Connor, Sarah E.

doi:10.1039/c6cc08438a

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Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis

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http://dx.doi.org/10.1039/c6cc08438a
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Citation

Jakubczyk, D., Caputi, L., Stevenson, C. E. M., Lawson, D. M., & O'Connor, S. E. (2016). Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis. Chemical Communications, 52(99), 14306-14309. doi:10.1039/c6cc08438a.

Cite as: https://hdl.handle.net/21.11116/0000-0002-B89A-1

Abstract

Aj_EasH is a non-heme iron-and alpha-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 A resolutn) reported here provides insight into the mechanism of this unusual and complex reaction.