J Refocused Coherence Transfer Spectroscopic Imaging at 7T

Pan, JW; Avdievich, NI; Hetherington , HP

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J Refocused Coherence Transfer Spectroscopic Imaging at 7T

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https://cds.ismrm.org/protected/10MProceedings/files/1_program.htm
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Pan, J., Avdievich, N., & Hetherington, H. (2010). J Refocused Coherence Transfer Spectroscopic Imaging at 7T. Poster presented at ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden.

Cite as: https://hdl.handle.net/21.11116/0000-0002-A511-0

Abstract

The detection of amino acids at ultra high field is enhanced due to improved spectral resolution in comparison to 3T. However, due to J-modulation and T2 losses short spin echo acquisitions are typically used at 7T. Unfortunately, broad macromolecule resonances, visible at short TE, can make accurate detection of the metabolites difficult. J refocused coherence transfer spectroscopy is known to suppress J-modulation of coupled spin systems, thereby allowing longer echo times and suppressing macromolecule contamination. We describe simulation and implementation of a J-refocused transfer sequence for spectroscopic imaging of glutamate and glutamine in the human brain at 7T.