Quantitative Magnetization Transfer Imaging in Postmortem Brain at 3T Using 
BSSFP

Soellinger, M; Langkammer, C; Seifert-Held, T; Krebs, N; Gloor, M; Scheurer, E; Scheffler, K; Fazekas, F; Ropele, S

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Quantitative Magnetization Transfer Imaging in Postmortem Brain at 3T Using BSSFP

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https://cds.ismrm.org/protected/10MProceedings/files/1_program.htm
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Soellinger, M., Langkammer, C., Seifert-Held, T., Krebs, N., Gloor, M., Scheurer, E., et al. (2010). Quantitative Magnetization Transfer Imaging in Postmortem Brain at 3T Using BSSFP. Poster presented at ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden.

Cite as: https://hdl.handle.net/21.11116/0000-0002-A517-A

Abstract

A crucial issue in determining quantitative magnetization transfer (qMT) parameters using balanced steady state free precession (bSSFP) is the estimation of the on-resonant singularity of the superlorentzian absorption line shape G0. We present an empirical G0 calibration method for postmortem in-situ brain scans at 3T using cross-linked BSA (bovine serum albumin) probes. For the investigated temperature range from 6-20°C G0 resulted in 2.0*10-5. First qMT results of three postmortem in-situ brain scans revealed decreased bound pool size ratios f in white matter compared to in-vivo scans.