Mapping the early spatiotemporal BOLD fMRI response in the barrel cortex of rats

Yu, X; Dodd, S; Hirano, Y; Saad, ZS; Reynolds, RC; Silva, AC; Koretsky, AP

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Meeting Abstract

Mapping the early spatiotemporal BOLD fMRI response in the barrel cortex of rats

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

https://cds.ismrm.org/protected/10MProceedings/files/1_program.htm
(Abstract)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Yu, X., Dodd, S., Hirano, Y., Saad, Z., Reynolds, R., Silva, A., et al. (2010). Mapping the early spatiotemporal BOLD fMRI response in the barrel cortex of rats. In ISMRM-ESMRMB Joint Annual Meeting 2010.

Cite as: https://hdl.handle.net/21.11116/0000-0002-A53F-E

Abstract

BOLD-fMRI signals increase in the rat somatosensory cortex faster than the transit time of blood moving from arteries to veins, which enables us to measure the evolution of BOLD responses at early times after stimulation. Here, the rat barrel cortex activity was mapped at 0.2s temporal resolution in 2D GE-EPI images at 150mmx150μmx500μm using an 11.7T MRI. Activity-evoked BOLD signals were first observed at 0.8s, and shifted to adjacent penetrating venules at 1-1.2s, later propagating to the superficial draining veins. This indicates that BOLD-fMRI maps made prior to about 1 s will have minimal contribution from penetrating cortical venules.