MR Spectroscopy without Water Suppression for the Determination of Proton 
Exchange Rates in the Human Brain

MacMillan, EL; Chong, DG; Dreher, W; Henning, A; Boesch, C; Kreis, R

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Meeting Abstract

MR Spectroscopy without Water Suppression for the Determination of Proton Exchange Rates in the Human Brain

MPG-Autoren

Es sind keine MPG-Autoren in der Publikation vorhanden

Externe Ressourcen

https://cds.ismrm.org/protected/10MProceedings/files/1_program.htm
(Zusammenfassung)

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Es sind keine frei zugänglichen Volltexte in PuRe verfügbar

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

MacMillan, E., Chong, D., Dreher, W., Henning, A., Boesch, C., & Kreis, R. (2010). MR Spectroscopy without Water Suppression for the Determination of Proton Exchange Rates in the Human Brain. In ISMRM-ESMRMB Joint Annual Meeting 2010.

Zitierlink: https://hdl.handle.net/21.11116/0000-0002-A544-7

Zusammenfassung

MRS without water suppression can detect exchangeable proton resonances, particularly downfield of water. Employing a two-acquisition scheme with alternating up- or down-field metabolite inversion prior to PRESS, both the metabolite and water spectra were obtained from the human brain in-vivo. The experiment was performed with and without a water inversion prepulse with varying inversion times (TI). The magnetization transfer curves were fit with a Bloch-McConnell two-site exchange model to determine exchange rates, with initial estimates yeilding lifetimes (1/Km¨w) ranging from 90ms to >2s, which offer information about pH and chemical microenvironments, and may aid in the understanding of CEST