Muscle group specific quantification of unsaturated fatty acids by localized 
DEPT-enhanced 13C MRS and ERETIC

Chen, X; Henning, A; Heinzer-Schweizer, S; Pavan, M; Bösiger, P

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Muscle group specific quantification of unsaturated fatty acids by localized DEPT-enhanced 13C MRS and ERETIC

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https://cds.ismrm.org/protected/10MProceedings/files/1_program.htm
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Chen, X., Henning, A., Heinzer-Schweizer, S., Pavan, M., & Bösiger, P. (2010). Muscle group specific quantification of unsaturated fatty acids by localized DEPT-enhanced 13C MRS and ERETIC. Poster presented at ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden.

Cite as: https://hdl.handle.net/21.11116/0000-0002-AA0A-4

Abstract

The quantification of metabolite concentrations of spatially specific 13C NMR spectra is questionable due to the low sensitivity. We propose a combined SNR enhancement by proton decoupling and ISIS-localized DEPT, aiming at muscle-group specific detection of unsaturated fatty acid in the calf muscle. Comparative measurements of four localized SNR enhancement sequences were performed with a 13C/1H dual-tune volume calf coil equipped with ERETIC. ERETIC signal intensity with and without proton decoupling as determined with TDFDfit was identical. This ISIS-localized DEPT combined with proton decoupling and the ERETIC reference standard technique can be easily extended to other muscle metabolites of interest.