Molecular aspects of DNA replication in Escherichia coli systems

Geider, Klaus

doi:10.1007/978-3-642-66336-9_3

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Molecular aspects of DNA replication in Escherichia coli systems

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Geider, Klaus
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Research Group Prof. Dr. Geider, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Geider, K. (1976). Molecular aspects of DNA replication in Escherichia coli systems. In Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung (pp. 55-112). Heidelberg: Springer.

Cite as: https://hdl.handle.net/21.11116/0000-0002-AE2F-7

Abstract

Since the discovery of the double helix by Watson and Crick, and the intensive studies of the Escherichia coli DNA polymerase I by Kornberg and coworkers, the understanding of DNA replication has been controversial in many aspects. Some basic ideas have been generally accepted: (1) the DNA is a helical double strand with antiparallel chains; (2) the immediate precursors for DNA synthesis are 5′-deoxynucleoside triphosphates; (3) the replication is semiconservative; and (4) all DNA is synthesized exclusively in 5′→3′ direction. The synthesis of larger DNA appears to be discontinuous in one or often both strands, and no DNA polymerase can start synthesis on a template without a primer.