An unusual defective genotype derived from herpes simplex virus strain ANG

Schröder, C.H.; Stegmann , B.; Lauppe, Hans-Frieder; Kaerner, Hans Christian

doi:10.1159/000149481

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An unusual defective genotype derived from herpes simplex virus strain ANG

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Lauppe, Hans-Frieder
Max Planck Institute for Medical Research, Max Planck Society;

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Kaerner, Hans Christian
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Schröder, C., Stegmann, B., Lauppe, H.-F., & Kaerner, H. C. (1975). An unusual defective genotype derived from herpes simplex virus strain ANG. Intervirology, 6(4-5), 270-284. doi:10.1159/000149481.

Cite as: https://hdl.handle.net/21.11116/0000-0002-B06B-F

Abstract

A defective genotype of herpes simplex virus strain Angelotti (HSV ANG) accumulates in the course of controlled serial high MOI virus passages representing 50–60% of the total number of mature virions in the seventh of these passages. Defective HSV ANG significantly differs from other defective HSV genotypes described so far: the DNA of the defective particles has the same buoyant density as nondefective DNA. In contrast to non-defective HSV ANG DNA, it is not attacked by the restriction endonucleases Eco R I, Hpa I and Hind III. Defective virions strongly suppress the formation of progeny virus. They do not interfere, however, with the synthesis of HSV-specified thymidine (TdR) kinase.