English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Dynamic Interactions in Synthetic Receptors: A Guest Exchange Saturation Transfer Study

MPS-Authors
/persons/resource/persons214560

Zaiss,  M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Avram, L., Havel, V., Shusterman-Krush, R., Iron, M., Zaiss, M., Sindelar, V., et al. (2019). Dynamic Interactions in Synthetic Receptors: A Guest Exchange Saturation Transfer Study. Chemistry – A European Journal, 25(7), 1687-1690. doi:10.1002/chem.201805973.


Cite as: http://hdl.handle.net/21.11116/0000-0002-B3B0-C
Abstract
The accumulated knowledge regarding molecular architectures is based on established, reliable and accessible analytical tools that provide robust structural and functional information on assemblies. However, both the dynamicity and low population of noncovalently interacting moieties within studied molecular systems limit the efficiency and accuracy of traditional methods. Herein, we demonstrate the use of a saturation transfer‐based NMR approach to study the dynamic binding characteristics of an anion to a series of synthetic receptors derived from bambusuril macrocycles. We show that the exchange rates of BF4‐ are mediated by the side chains on the receptor (100 s 1<kex<5000 s 1), which play a critical role in receptor‐anion binding dynamics. The signal amplification obtained with this approach allows us to identify different types of intermolecular interactions between the receptor and the anion, something that could not have been detected by techniques hitherto used to study molecular assemblies. These findings, which are supported by a computational molecular dynamic study, demonstrate the uniqueness and added value of this NMR method.