English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

MPS-Authors
/persons/resource/persons212777

Janssen,  Lieneke
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Locator
There are no locators available
Fulltext (public)

Sescousse_2018.pdf
(Publisher version), 518KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Sescousse, G., Ligneul, R., van Holst, R. J., Janssen, L., de Boer, F., Janssen, M., et al. (2018). Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation. European Journal of Neuroscience, 47(9), 1081-1086. doi:10.1111/ejn.13895.


Cite as: http://hdl.handle.net/21.11116/0000-0002-B4A8-5
Abstract
Dopamine is central to a number of cognitive functions and brain disorders. Given the cost of neurochemical imaging in humans, behavioural proxy measures of dopamine have gained in popularity in the past decade, such as spontaneous eye blink rate (sEBR). Increased sEBR is commonly associated with increased dopamine function based on pharmacological evidence and patient studies. Yet, this hypothesis has not been validated using in vivo measures of dopamine function in humans. To fill this gap, we measured sEBR and striatal dopamine synthesis capacity using [18F]DOPA PET in 20 participants (nine healthy individuals and 11 pathological gamblers). Our results, based on frequentist and Bayesian statistics, as well as region‐of‐interest and voxel‐wise analyses, argue against a positive relationship between sEBR and striatal dopamine synthesis capacity. They show that, if anything, the evidence is in favour of a negative relationship. These results, which complement findings from a recent study that failed to observe a relationship between sEBR and dopamine D2 receptor availability, suggest that caution and nuance are warranted when interpreting sEBR in terms of a proxy measure of striatal dopamine.