Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Deterministic fate assignment of Muller glia cells in the zebrafish retina suggests a clonal backbone during development

MPG-Autoren
/persons/resource/persons217188

Rulands,  Steffen
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

Externe Ressourcen

https://onlinelibrary.wiley.com/doi/full/10.1111/ejn.14257
(Verlagsversion)

Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Rulands, S., Iglesias-Gonzalez, A. B., & Boije, H. (2018). Deterministic fate assignment of Muller glia cells in the zebrafish retina suggests a clonal backbone during development. European Journal of Neuroscience, 48(12), 3597-3605. doi:10.1111/ejn.14257.


Zitierlink: https://hdl.handle.net/21.11116/0000-0002-BDB3-F
Zusammenfassung
The optic cup houses multipotent retinal progenitor cells that proliferate and differentiate to form the mature retina, containing five main types of neurons and a single glial cell type, the Muller cell. Progenitors of the zebrafish optic cup generate clones that vary regarding the number and types of neurons, a process we previously showed could be described by stochastic models. Here, we present data indicating that each retinal progenitor cell, in the 24 hrs post-fertilization optic cup, is predestined to form a single Muller cell. This striking fate assignment of Muller cells reveals a dual nature of retinal lineages where stochastic mechanisms produce variable numbers of neurons while there is a strong deterministic component governing the formation of glia cells. A possible mechanism for this stereotypic fate assignment could be the maintenance of a clonal backbone during retina development, which would be similar to invertebrate and rodent cortical neurogenesis.