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Journal Article

Specific hippocampal choline decrease in an animal model of depression

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Hong,  S-T
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.birpublications.org/doi/10.1259/bjr/25165760
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Citation

Hong, S.-T., Choi, C.-B., Park, C., Park, C., Moon, H.-Y., Hong, K.-S., et al. (2009). Specific hippocampal choline decrease in an animal model of depression. British Journal of Radiology, 82(879), 549-553. doi:10.1259/bjr/25165760.


Cite as: https://hdl.handle.net/21.11116/0000-0002-BF96-E
Abstract
A decreased level of the hippocampal choline signal was found in patients with depression in previous proton magnetic resonance spectroscopy (1H-MRS) studies. The objective of this study is to compare choline levels before and after the forced swimming test (FST), an animal model of depression typically used for assessing antidepressant activity. 1H-MRS spectra were obtained from both the left and right hippocampus. After the FST, rats showed a significant decrease of the choline/creatine (Cho/Cr, p = 0.037) and choline/N-acetylaspartate (Cho/NAA, p = 0.048) ratios in the left hippocampus, but not in the right hippocampus. This finding was analogous to results from patients with depression. It suggests that decreased Cho/Cr and Cho/NAA ratios in the left hippocampal regions might be considered to be biomarkers in rats with depression.