Ca transport of sarcoplasmic reticulum during experimental uremia

Heimberg, K.-W.; Matthews, C.; Ritz, E.

doi:10.1007/BF02546428

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Ca transport of sarcoplasmic reticulum during experimental uremia

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Heimberg, K.-W.
Max Planck Institute for Medical Research, Max Planck Society;

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Heimberg, K.-W., Matthews, C., & Ritz, E. (1976). Ca transport of sarcoplasmic reticulum during experimental uremia. Calcified Tissue Research, 21(Suppl1), 53-58. doi:10.1007/BF02546428.

Cite as: https://hdl.handle.net/21.11116/0000-0002-C3E0-4

Abstract

In uremia, the membrane composition of the SR is altered: the ATPase carrier complex decreases, the phosphatide, but not the cholesterol content of the membranes decreases and the fatty acid pattern changes. All these lipid changes are known to affect the kinetic properties of lipoprotein enzymes (6, 7, 8). In uremia the altered lipoprotein interactions of the membrane are paralleled by an impairment of nearly all kinetic parameters of the SR.