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Journal Article

Active Ca transport of sarcoplasmic reticulum during experimental uremia

MPS-Authors
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Heimberg,  K.-W.
Max Planck Institute for Medical Research, Max Planck Society;

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Augustin,  Jan
Max Planck Institute for Medical Research, Max Planck Society;

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Hasselbach,  Wilhelm
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://febs.onlinelibrary.wiley.com/doi/epdf/10.1111/j.1432-1033.1976.tb10013.x
(Any fulltext)

https://doi.org/10.1111/j.1432-1033.1976.tb10013.x
(Any fulltext)

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Citation

Heimberg, K.-W., MATTHEWS, C., RITZ, E., Augustin, J., & Hasselbach, W. (1976). Active Ca transport of sarcoplasmic reticulum during experimental uremia. European Journal of Biochemistry, 61(1), 207-213. doi:10.1111/j.1432-1033.1976.tb10013.x.


Cite as: https://hdl.handle.net/21.11116/0000-0002-C3FB-7
Abstract
The Ca‐transport system of sarcoplasmic vesicles of rabbits is altered by experimental uremia.

1

The influx rate constant of the experimental membranes decrease with a resulting decrease of the calcium influx rate.
2

The experimental membranes transport a smaller amount of Ca2+ per mol of ATP split than the controls, i.e. their transport ratio is decreased.
3

The calcium permeability of the experimental membranes increases with a resulting decreased concentrating ability.
4

The phosphatide content but not the cholesterol content of the experimental membranes decreases with a consequent increase of the cholesterol/phosphatide ratio.
5

The fatty acid pattern of total phosphatides of the experimental membranes changes. A relative decrease of palmitic acid and oleic acid occurs and a relative increase of stearic, arachidonic and higher unsaturated fatty acids.
6

The altered lipid composition of the membranes does not change the temperature dependence of the kinetics.