Dual effect of Ca2+ on ultrasonic ATPase activity and polymerization of muscle 
actin

Dancker, Peter; Löw, Irmentraut

doi:10.1016/0005-2744(77)90122-X

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Dual effect of Ca2+ on ultrasonic ATPase activity and polymerization of muscle actin

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Dancker, Peter
Max Planck Institute for Medical Research, Max Planck Society;

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Löw, Irmentraut
Max Planck Institute for Medical Research, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/000527447790122X/pdf?md5=26222d0d4dea050dc96216c82ebfb170&pid=1-s2.0-000527447790122X-main.pdf
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Citation

Dancker, P., & Löw, I. (1977). Dual effect of Ca2+ on ultrasonic ATPase activity and polymerization of muscle actin. Biochimica et Biophysica Acta: BBA, 484(1), 169-176. doi:10.1016/0005-2744(77)90122-X.

Cite as: https://hdl.handle.net/21.11116/0000-0002-C7C9-B

Abstract

Millimolar concentrations of Ca2+ stimulate actin polymerization whereas micromolar concentration of Ca2+ depress polymerization. This latter effect leads to a reduction of ATPase (ATP phosphohydrolase, EC 3.6.1.3) activity of actin during sonication of low Mg2+ concentrations and in the absence of KCl. In the presence of KCl (90 mM) there is activation of ATPase activity by micromolar Ca2+ concentrations. These Ca2+ effects are half-maximal at a Ca2+ concentration of 2 · 10−7 M. They can be explained by assuming that ATPase activity is optimal in a medium range of actin polymer stability and that micromolar Ca2+ concentrations tend to labilize and depolymerize F-actin.