English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly

MPS-Authors
/persons/resource/persons188905

Lampe,  Leonie
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

/persons/resource/persons98578

Kharabian,  Shahrzad
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons183334

Kynast,  Jana
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19531

Arélin,  Katrin
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons81144

Steele,  Christopher
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montréal, QC, Cananda;

/persons/resource/persons128137

Witte,  A. Veronica
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19981

Schroeter,  Matthias L.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

/persons/resource/persons20065

Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

/persons/resource/persons23475

Bazin,  Pierre-Louis
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Lampe, L., Kharabian, S., Kynast, J., Arélin, K., Steele, C., Löffler, M., et al. (2019). Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly. Journal of Cerebral Blood Flow and Metabolism, 39(1), 36-43. doi:10.1177/0271678X17740501.


Cite as: http://hdl.handle.net/21.11116/0000-0002-CFAF-1
Abstract
White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort (n = 702, age range 60 – 82 years, mean age = 69.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter—including the corticospinal tract—compromised motor speed performance. This study exposes the subtle and subclinical yet detrimental effects of WMH on cognition in healthy elderly, and strongly suggests a causal influence of WMH on cognition by demonstrating the spatial specificity of these effects.