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Right time, right place-DNA damage and DNA replication checkpoints collectively safeguard S phase

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Galanti,  Lorenzo
Pfander, Boris / DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Max Planck Society;

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Pfander,  Boris
Pfander, Boris / DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Max Planck Society;

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e100681.full.pdf
(Publisher version), 214KB

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Citation

Galanti, L., & Pfander, B. (2018). Right time, right place-DNA damage and DNA replication checkpoints collectively safeguard S phase. EMBO Journal, 37(21): e100681. doi:10.15252/embj.2018100681.


Cite as: http://hdl.handle.net/21.11116/0000-0002-EE1D-3
Abstract
The DNA replication checkpoint (DRC) and the DNA damage checkpoint (DDC) are two closely linked signaling cascades that adjust S phase to the presence of DNA lesions and other replication impediments. Two recent studies published in The EMBO Journal shed new light on their relationship in budding yeast, collectively showing that the two pathways-while sharing several factors-differ in the location and kinetics of their activation, suggesting that they constitute different branches of an integrated cellular response to impaired DNA replication.