The Kank family proteins in adhesion dynamics

Chen, Nan-Peng; Sun, Zhiqi; Fässler, Reinhard

doi:10.1016/j.ceb.2018.05.015

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The Kank family proteins in adhesion dynamics

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Chen, Nan-Peng
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Fässler, Reinhard
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Chen, N.-P., Sun, Z., & Fässler, R. (2018). The Kank family proteins in adhesion dynamics. Current Opinion in Cell Biology, 54, 130-136. doi:10.1016/j.ceb.2018.05.015.

Cite as: https://hdl.handle.net/21.11116/0000-0002-F211-9

Abstract

Integrin-mediated cell adhesion plays key roles for cell movement during development and tissue homeostasis. The dynamic life cycle of various integrin adhesions structures is required for the cell movements and regulated by the coordinated actions of both actomyosin and the microtubule (MT) cytoskeleton. The evolutionarily conserved Kank family proteins have emerged as regulators of adhesion dynamics by coordinating integrin-mediated force transmission with the recruitment of microtubules to integrins. These novel functions may play important roles in vivo and in human diseases.