Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Archaeal cell surface biogenesis


Pfeiffer,  Friedhelm
Habermann, Bianca / Computational Biology, Max Planck Institute of Biochemistry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

(Publisher version), 2MB

Supplementary Material (public)

(Supplementary material), 747KB


Pohlschroder, M., Pfeiffer, F., Schulze, S., & Halim, M. F. A. (2018). Archaeal cell surface biogenesis. FEMS Microbiology Reviews, 42(5), 694-717. doi:10.1093/femsre/fuy027.

Cite as: https://hdl.handle.net/21.11116/0000-0002-FAE1-6
Cell surfaces are critical for diverse functions across all domains of life, from cell-cell communication and nutrient uptake to cell stability and surface attachment. While certain aspects of the mechanisms supporting the biosynthesis of the archaeal cell surface are unique, likely due to important differences in cell surface compositions between domains, others are shared with bacteria or eukaryotes or both. Based on recent studies completed on a phylogenetically diverse array of archaea, from a wide variety of habitats, here we discuss advances in the characterization of mechanisms underpinning archaeal cell surface biogenesis. These include those facilitating co- and post-translational protein targeting to the cell surface, transport into and across the archaeal lipid membrane, and protein anchoring strategies. We also discuss, in some detail, the assembly of specific cell surface structures, such as the archaeal S-layer and the type IV pili. We will highlight the importance of post-translational protein modifications, such as lipid attachment and glycosylation, in the biosynthesis as well as the regulation of the functions of these cell surface structures and present the differences and similarities in the biogenesis of type IV pili across prokaryotic domains.