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Journal Article

Recognition of phylogenetic relationships from polypeptide chain fold similarities

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Schulz,  Georg E.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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https://link.springer.com/content/pdf/10.1007%2FBF01796096.pdf
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https://doi.org/10.1007/BF01796096
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Citation

Schulz, G. E. (1977). Recognition of phylogenetic relationships from polypeptide chain fold similarities. Journal of Molecular Evolution: the Journal of the International Society of Molecular Evolution, 9(4), 339-342. doi:10.1007/BF01796096.


Cite as: https://hdl.handle.net/21.11116/0000-0002-D871-B
Abstract
Structural similarities between proteins with no amino acid sequence homology either indicate a phylogenetic relationship, or they are merely the expression of a physically preferred way of folding a polypeptide chain. It is shown that one can distinguish between these alternatives by evaluating the “significance of the similarity”. Such significances have been derived for comparison between chain folds containingβ-pleated sheets (Schulz and Schirmer, 1974; Richardson et al., 1976; Sternberg and Thornton, 1976). An extension of this method to comparisons between any two chain folds is outlined here.