Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Recognition of phylogenetic relationships from polypeptide chain fold similarities


Schulz,  Georg E.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Schulz, G. E. (1977). Recognition of phylogenetic relationships from polypeptide chain fold similarities. Journal of Molecular Evolution: the Journal of the International Society of Molecular Evolution, 9(4), 339-342. doi:10.1007/BF01796096.

Cite as: https://hdl.handle.net/21.11116/0000-0002-D871-B
Structural similarities between proteins with no amino acid sequence homology either indicate a phylogenetic relationship, or they are merely the expression of a physically preferred way of folding a polypeptide chain. It is shown that one can distinguish between these alternatives by evaluating the “significance of the similarity”. Such significances have been derived for comparison between chain folds containingβ-pleated sheets (Schulz and Schirmer, 1974; Richardson et al., 1976; Sternberg and Thornton, 1976). An extension of this method to comparisons between any two chain folds is outlined here.