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Journal Article

Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis

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Citation

Franke, J., Kim, J., Hamilton, J. P., Zhao, D., Pham, G. M., Wiegert-Rininger, K., et al. (2019). Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis. Chembiochem, 20(1), 83-87. doi:10.1002/cbic.201800592.


Cite as: https://hdl.handle.net/21.11116/0000-0002-D8AF-6
Abstract
Genome mining is a routine technique in microbes for discovering biosynthetic pathways. In plants, however, genomic information
is not commonly used to identify novel biosynthesis
genes. Here, we present the genome of the medicinal plant
and oxindole monoterpene indole alkaloid (MIA) producer Gelsemium
sempervirens (Gelsemiaceae). A gene cluster from Catharanthus
roseus, which is utilized at least six enzymatic steps
downstream from the last common intermediate shared between
the two plant alkaloid types, is found in G. sempervirens,
although the corresponding enzymes act on entirely different
substrates. This study provides insights into the common genomic
context of MIA pathways and is an important milestone
in the further elucidation of the Gelsemium oxindole alkaloid pathway.