High-throughput single-cell transcriptomics on organoids

Brazovskaja, Agnieska; Treutlein, Barbara; Camp, J. Gray

doi:10.1016/j.copbio.2018.11.002

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High-throughput single-cell transcriptomics on organoids

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Brazovskaja, Agnieska
Single Cell Genomics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Treutlein, Barbara
Single Cell Genomics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Camp, J. Gray
Modern and Archaic Human Cell Biology, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Citation

Brazovskaja, A., Treutlein, B., & Camp, J. G. (2019). High-throughput single-cell transcriptomics on organoids. Current Opinion in Biotechnology, 55, 167-171. doi:10.1016/j.copbio.2018.11.002.

Cite as: https://hdl.handle.net/21.11116/0000-0002-DB71-8

Abstract

Three-dimensional (3D) tissues grown in culture from human stem cells offer the incredible opportunity to analyze and manipulate human development, and to generate patient-specific models of disease. Methods to sequence DNA and RNA in single cells are being used to analyze these so-called ‘organoid’ systems in high-resolution. Single-cell transcriptomics has been used to quantitate the similarity of organoid cells to primary tissue counterparts in the brain, intestine, liver, and kidney, as well as identify cell-specific responses to environmental variables and disease conditions. The merging of these two technologies, single-cell genomics and organoids, will have profound impact on personalized medicine in the near future.