Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular 
Fatty Acid Trafficking

Cohen, Sarah; Rambold, Angelika; Lippincott-Schwartz, Jennifer

doi:10.1080/23723556.2015.1043038

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Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking

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Rambold, Angelika
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Cohen, S., Rambold, A., & Lippincott-Schwartz, J. (2018). Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking. Molecular and Cellular Oncology, 5, e1043038. doi:10.1080/23723556.2015.1043038.

Cite as: https://hdl.handle.net/21.11116/0000-0003-6DE5-1

Abstract

Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were replenished with FAs supplied by autophagy. These findings have important implications for cancer.