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Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults

MPS-Authors
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Schaare,  Herma Lina
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
International Max Planck Research School on Neuroscience of Communication, Leipzig, Germany;

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Kharabian,  Shahrzad
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Beyer,  Frauke
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;

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Kumral,  Deniz
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Uhlig,  Marie
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
International Max Planck Research School on Neuroscience of Communication, Leipzig, Germany;

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Reinelt,  Janis
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Reiter,  Andrea
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Lifespan Developmental Neuroscience, Department of Biological Psychology, Faculty of Psychology, TU Dresden, Germany;

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Lampe,  Leonie
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Babayan,  Anahit
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Erbey,  Miray
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Röbbig,  Josefin
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Schroeter,  Matthias L.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Mueller,  Karsten
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Mendes,  Natacha
Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Margulies,  Daniel S.
Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Witte,  A. Veronica
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;

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Gaebler,  Michael
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;
Lifespan Developmental Neuroscience, Department of Biological Psychology, Faculty of Psychology, TU Dresden, Germany;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;
Lifespan Developmental Neuroscience, Department of Biological Psychology, Faculty of Psychology, TU Dresden, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;
Center for Stroke Research, Charité University Medicine Berlin, Germany;

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Citation

Schaare, H. L., Kharabian, S., Beyer, F., Kumral, D., Uhlig, M., Reinelt, J., et al. (2019). Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults. Neurology, 92(8), e758-e773. doi:10.1212/WNL.0000000000006947.


Cite as: http://hdl.handle.net/21.11116/0000-0002-E0E6-D
Abstract
Objective To test whether elevated blood pressure (BP) relates to gray matter (GM) volume (GMV) changes in young adults who had not previously been diagnosed with hypertension (systolic BP [SBP]/diastolic BP [DBP] ≥140/90 mm Hg). Methods We associated BP with GMV from structural 3T T1-weighted MRI of 423 healthy adults between 19 and 40 years of age (mean age 27.7 ± 5.3 years, 177 women, SBP/DBP 123.2/73.4 ± 12.2/8.5 mm Hg). Data originated from 4 previously unpublished cross-sectional studies conducted in Leipzig, Germany. We performed voxel-based morphometry on each study separately and combined results in image-based meta-analyses (IBMA) to assess cumulative effects across studies. Resting BP was assigned to 1 of 4 categories: (1) SBP <120 and DBP <80 mm Hg, (2) SBP 120–129 or DBP 80–84 mm Hg, (3) SBP 130–139 or DBP 85–89 mm Hg, (4) SBP ≥140 or DBP ≥90 mm Hg. Results IBMA yielded the following results: (1) lower regional GMV was correlated with higher peripheral BP; (2) lower GMV was found with higher BP when comparing individuals in subhypertensive categories 3 and 2, respectively, to those in category 1; (3) lower BP-related GMV was found in regions including hippocampus, amygdala, thalamus, frontal, and parietal structures (e.g., precuneus). Conclusion BP ≥120/80 mm Hg was associated with lower GMV in regions that have previously been related to GM decline in older individuals with manifest hypertension. Our study shows that BP-associated GM alterations emerge continuously across the range of BP and earlier in adulthood than previously assumed. This suggests that treating hypertension or maintaining lower BP in early adulthood might be essential for preventing the pathophysiologic cascade of asymptomatic cerebrovascular disease to symptomatic end-organ damage, such as stroke or dementia.