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Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin

MPG-Autoren

Sanin,  David E.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Matsushita,  Mai
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Klein-Geltink,  Ramon
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Grzes,  Katarzyna
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

van Bakker,  Nikki Teijlingen
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Corrado,  Mauro
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Kabat,  Agnieska
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Buck,  Michael D.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;
External Organizations;

Qiu,  Jing
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;
External Organizations;

Lawless,  Simon J.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Cameron,  Alana
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Villa,  Matteo
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Baixauli Celda,  Francesc
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Patterson,  Annette E.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Hässler,  Fabian
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Curtis,  Jonathan D.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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O'Sullivan,  David
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Mittler,  Gerhard
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Huang,  Stanley Ching-Cheng
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Pearce,  Erika L.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Pearce,  Edward J.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Externe Ressourcen

https://www.sciencedirect.com/science/article/pii/S107476131830476X?via%3Dihub
(Verlagsversion)

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Zitation

Sanin, D. E., Matsushita, M., Klein-Geltink, R., Grzes, K., van Bakker, N. T., Corrado, M., et al. (2018). Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin. Immunity, 49, 1021-1033. doi:org/10.1016/j.immuni.2018.10.011.


Zitierlink: https://hdl.handle.net/21.11116/0000-0003-6DFB-9
Zusammenfassung
Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effects on Δψm were a consequence of PGE2-initiated transcriptional regulation of genes, particularly Got1, in the malate-aspartate shuttle (MAS). Reduced Δψm caused alterations in the expression of 126 voltage-regulated genes (VRGs), including those encoding resistin-like molecule α (RELMα), a key marker of M(IL-4) cells, and genes that regulate the cell cycle. The transcription factor ETS variant 1 (ETV1) played a role in the regulation of 38% of the VRGs. These results reveal ETV1 as a Δψm-sensitive transcription factor and Δψm as a mediator of mitochondrial-directed nuclear gene expression.