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Reduced bonobo MHC class I diversity predicts a reduced viral peptide binding ability compared to chimpanzees

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Maibach,  Vincent
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Vigilant,  Linda
Molecular Genetics Laboratory, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Maibach_Reduced_BMCEvoBio_2019.pdf
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Citation

Maibach, V., & Vigilant, L. (2019). Reduced bonobo MHC class I diversity predicts a reduced viral peptide binding ability compared to chimpanzees. BMC Evolutionary Biology, 19: 14. doi:10.1186/s12862-019-1352-0.


Cite as: http://hdl.handle.net/21.11116/0000-0002-E3B9-D
Abstract
The highly polymorphic genes of the major histocompatibility complex (MHC) class I are involved in defense against viruses and other intracellular pathogens. Although several studies found reduced MHC class I diversity in bonobos in comparison to the closely related chimpanzee, it is unclear if this lower diversity also influences the functional ability of MHC class I molecules in bonobos. Here, we use a bioinformatic approach to analyze the viral peptide binding ability of all published bonobo MHC class I molecules (n =þinspace}58) in comparison to all published chimpanzee MHC class I molecules (n ={þinspace161) for the class I loci A, B, C and A-like.