How DNA vicinity controls SUMO E3 ligase activity

Pichler, Andrea

doi:10.15252/embj.201899705

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How DNA vicinity controls SUMO E3 ligase activity

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Pichler, Andrea
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Pichler, A. (2018). How DNA vicinity controls SUMO E3 ligase activity. EMBO Journal, e99705. doi:10.15252/embj.201899705.

Cite as: https://hdl.handle.net/21.11116/0000-0003-6E01-1

Abstract

Little is known about the regulation of SUMO E3 ligases and how they are activated upon stress. New findings from the Reverter and Torres-Rosell laboratories in The EMBO Journal demonstrate that vicinity of preferentially ssDNA activates the SUMO E3 ligase Nse2 when in complex with SMCS-6.