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Palladium-Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature

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Pan,  Fei
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Boursalian,  Gregory B.
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Ritter,  Tobias
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Pan, F., Boursalian, G. B., & Ritter, T. (2018). Palladium-Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature. Angewandte Chemie International Edition, 57(51), 16871-16876. doi:10.1002/anie.201811139.


Cite as: https://hdl.handle.net/21.11116/0000-0003-575A-7
Abstract
Methods for the direct synthesis of difluoromethylated arenes are sparse, despite the importance of the difluoromethyl group in medical, agro‐, and materials chemistry. A palladium‐catalyzed decarbonylative cross‐coupling reaction of acid chlorides with a difluoromethyl zinc reagent is achieved to access difluoromethylated compounds. The transformation proceeds at room temperature and shows broad functional group tolerance, thus providing a general and efficient method for decarbonylative difluoromethylation of a wide range of aromatic carboxylic acids.