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Journal Article

Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

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Lenz,  Tobias L.
Emmy Noether Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;
Research Group Evolutionary Immunogenomics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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journal.pbio.3000131.pdf
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Citation

Manczinger, M., Boross, G., Kemény, L., Müller, V., Lenz, T. L., Papp, B., et al. (2019). Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations. PLoS Biology, 17(1): e3000131. Retrieved from https://doi.org/10.1371/journal.pbio.3000131.


Cite as: http://hdl.handle.net/21.11116/0000-0002-F74E-1
Abstract
Whereas specialist major histocompatibility complex (MHC) molecules initiate immune response against only relatively few pathogens, generalists provide protection against a broad range. Accordingly, this study shows that the geographical distribution of generalist MHC alleles in human populations reflects exposure to diverse infectious diseases.