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Journal Article

A study of within-subject reliability of the brain’s default-mode network

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Postema,  Merel
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;
Department of Neuroscience, University of Sheffield;
Faculty of Earth and Life Sciences, VU University;
International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society;

De Marco,  Matteo
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;

Colato,  Elisa
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;

Venneri,  Annalena
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;

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Citation

Postema, M., De Marco, M., Colato, E., & Venneri, A. (2019). A study of within-subject reliability of the brain’s default-mode network. Magnetic Resonance Materials in Physics, Biology and Medicine, 32(3), 391-405. doi:10.1007/s10334-018-00732-0.


Cite as: https://hdl.handle.net/21.11116/0000-0002-FB32-B
Abstract
Objective

Resting-state functional magnetic resonance imaging (fMRI) is promising for Alzheimer’s disease (AD). This study aimed to examine short-term reliability of the default-mode network (DMN), one of the main haemodynamic patterns of the brain.
Materials and methods

Using a 1.5 T Philips Achieva scanner, two consecutive resting-state fMRI runs were acquired on 69 healthy adults, 62 patients with mild cognitive impairment (MCI) due to AD, and 28 patients with AD dementia. The anterior and posterior DMN and, as control, the visual-processing network (VPN) were computed using two different methodologies: connectivity of predetermined seeds (theory-driven) and dual regression (data-driven). Divergence and convergence in network strength and topography were calculated with paired t tests, global correlation coefficients, voxel-based correlation maps, and indices of reliability.
Results

No topographical differences were found in any of the networks. High correlations and reliability were found in the posterior DMN of healthy adults and MCI patients. Lower reliability was found in the anterior DMN and in the VPN, and in the posterior DMN of dementia patients.
Discussion

Strength and topography of the posterior DMN appear relatively stable and reliable over a short-term period of acquisition but with some degree of variability across clinical samples.