English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Mapping Optogenetically Driven Single-Vessel fMRI with Concurrent Neuronal Calcium Recordings in the Rat Hippocampus

MPS-Authors
/persons/resource/persons214920

Chen,  X-M
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214934

Sobczak,  F
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214924

Chen,  Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84063

Logothetis,  NK
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Chen, X.-M., Sobczak, F., Chen, Y., Qian, C., Lu, Z., Ayata, C., et al. (2019). Mapping Optogenetically Driven Single-Vessel fMRI with Concurrent Neuronal Calcium Recordings in the Rat Hippocampus. Neuron, Epub ahead. doi:10.2139/ssrn.3318946.


Cite as: http://hdl.handle.net/21.11116/0000-0003-054F-0
Abstract
The hippocampus plays critical roles in learning and memory, as well as pathological states such as epilepsy and Alzheimer’s disease. To better understand its neural network function, the multi-modality methodology has been implemented in both in vitro and in vivo conditions. However, the large-scale hippocampal vascular hemodynamic responses linked to specific neural activity remains to be elucidated at the single-vessel level through the hippocampus. We merged the fiber optic calcium recording with optogenetically driven single-vessel fMRI to obtain concurrent neuronal calcium signal with blood-oxygen-level-dependent and cerebral-blood-volume (CBV) signal from individual venules and arterioles, respectively, which are aligned in an interleaved pattern to circulate blood through the hippocampus. This multi-modal fMRI platform detects specific spatiotemporal hemodynamic patterns from hippocampal vasculature correlated with physiologically evoked and spreading depression-like calcium events. The calcium event-related single-vessel fMRI hemodynamic modeling reveals significantly reduced neurovascular coupling efficiency upon spreading depression-like events, providing a direct measure of the hippocampal vascular function at varied states in animal models.