In-vivo measurement of absolute metabolite concentrations using the ERETIC 
method

Heinzer-Schweizer, S; De Zanche, N; Pavan, M; Mens, G; Sturzenegger, U; Henning, A; Boesiger, P

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In-vivo measurement of absolute metabolite concentrations using the ERETIC method

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https://cds.ismrm.org/protected/09MProceedings/files/1_program.htm
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Heinzer-Schweizer, S., De Zanche, N., Pavan, M., Mens, G., Sturzenegger, U., Henning, A., et al. (2009). In-vivo measurement of absolute metabolite concentrations using the ERETIC method. In 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009).

Cite as: https://hdl.handle.net/21.11116/0000-0003-15EE-A

Abstract

Absolute quantification is an indispensable tool to precisely determine metabolite changes. Calibration with ERETIC (Electric REference To access In vivo Concentrations), whereby a synthetic reference signal is injected during the acquisition of spectra, was used to determine quantitative in-vivo metabolite concentrations in volunteers. Brain 1H MRS spectra were acquired and cross-validated against the internal water reference method. The results of both calibration techniques were in good agreement in healthy tissue. In addition, the ERETIC setup was perfected by substitution of the electrical by an optical signal transmission line to eliminate fluctuations of the ERETIC signal intensity due to parasitic coupling.