31P Exchange Sensitive Imaging in Human Brain at 7T

Pan, JW; Avdievich, N; Spencer, D; Hetherington, HP

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31P Exchange Sensitive Imaging in Human Brain at 7T

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https://cds.ismrm.org/protected/09MProceedings/files/1_program.htm
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Pan, J., Avdievich, N., Spencer, D., & Hetherington, H. (2009). 31P Exchange Sensitive Imaging in Human Brain at 7T. In 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009).

Cite as: https://hdl.handle.net/21.11116/0000-0003-15F4-2

Abstract

As a functional measure of bioenergetic state in human brain, 31P MRS is sensitive to effects of relaxation, concentration and chemical exchange. While the sensitivity to creatine kinase has been well used in muscle spectroscopy with saturation transfer experiments it has been less developed for brain. Given that creatine kinase rates have demonstrated sensitivity to physiologic condition it may be informative for pathologic state. We implemented exchange sensitive weighting to the 31P spectroscopic imaging acquisition, parameters based on 3site exchange simulations to ascertain sensitivity to varying levels of exchange. We demonstrate this approach in controls and epilepsy patients at 7T.